Pharmaceuticals can be classified into inorganic, organic compounds as well as excipients. The need to have a readily adaptable method for the quality control of these compounds has led to the development of a wide range of reactions and procedures. Majority of these pharmaceuticals lack adequate chromophores which can permit analysis at wavelength regions beyond the nonspecific UV‐region of the electromagnetic spectrum. Thus derivatization reactions are carried out to convert these pharmaceuticals to readily determinable compounds whose properties and concentrations can be related to the original compound. The need to have simple methods for the analysis of pharmaceuticals, in spite of the improvement in modern‐day technology, will continue to make these derivatization methodologies relevant in the quality control of these compounds especially in poor‐resource economies. The aim of present work is to find out a simple, specific, colorimetric or visible-spectrophotometric method using analytical and chemical reagents in bulk and pharmaceutical formulations. In present work different reagents, their properties, uses, mechanism of action and applications are enlisted.
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